With no service interval to go by, you need to pay attention to the chains.
The first symptom is noise in the timing system.
The chains slap around because of worn tensioners and guides.
The common sound is “marbles in a can.”
Failed guides can cause the chains to jump, skip a tooth and potentially snap.
Because the VR6 is an interference motor, a snapped chain or one that has jumped a tooth means that valves can contact the pistons and cause catastrophic engine failure.